Insight into early stages of bowel cancer could provide new treatments

An international team of scientists have identified key factors underpinning the development of bowel or colorectal cancer in patients with a genetic predisposition to the disease. The study—led by researchers at the Cancer Research UK Beatson Institute at the University of Glasgow and the University of Helsinki, and published today in Nature—provides crucial insight into […]

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Functional brain network predicts real-life social network in individuals with schizophrenia, social anhedonia

Schizophrenia is a brain and neurodevelopmental disorder. Previous studies on schizophrenia have mainly focused on the identification of sub-networks associating with social cognitions such as mentalizing people’s intention and understanding their emotion. However, few studies have examined the social brain network and its role in the formation of various social dysfunctions in patients with schizophrenia. […]

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New structures show how auxiliary subunits modulate hippocampal AMPA receptor neurotransmission

Our brains are made up of networks of neurons where each individual nerve cell can make connections with thousands of others. AMPA receptors are a set of membrane proteins that mediate fast signal transmission across these connection points called synapses, with certain receptor complexes predominating in different parts of the brain. Ingo Greger’s group, in […]

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Novel antibody drug wakes up the body’s defense system in advanced-stage cancer

Researchers at the University of Turku, Finland, showed that the antibody treatment reactivates the immune defense in patients with advanced-stage cancer. The treatment alters the function of the body’s phagocytes and facilitates extensive activation of the immune system. The immune defense is the body’s own defense system equipped to combat cancer. However, cancer learns to […]

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Analysis of 4,000 drugs reveals an alternative mechanism for a new anticancer therapy

By analyzing 4,000 drugs’ ability to affect cells’ capacity to produce proteins, researchers at Karolinska Institutet found that an anticancer therapy currently trialed in human patients works differently than previously thought. As many human diseases have alterations in this process called translation, the new knowledge contributes to a better understanding of how translation is regulated […]

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